Cardarine (GW‑501516) is an orally active, non-steroidal metabolic modulator that selectively binds to the PPARδ (Peroxisome Proliferator-Activated Receptor delta), a nuclear receptor involved in the regulation of energy metabolism. By activating PPARδ, Cardarine upregulates the expression of genes responsible for fatty acid transport, oxidation, and overall energy utilization in skeletal muscle and other tissues. This mechanism enhances endurance performance by increasing the muscles’ capacity to use lipids as an energy source, improves metabolic efficiency, and supports favorable shifts in body composition by promoting fat loss while preserving lean muscle mass. Cardarine also influences multiple signaling pathways involved in mitochondrial biogenesis, cellular energy homeostasis, and tissue repair, contributing to improved recovery and sustained metabolic activity. Unlike anabolic agents, Cardarine exerts its effects without directly interacting with androgen receptors, minimizing the risk of androgenic or steroid-related side effects. Its selective modulation of metabolic pathways makes it a powerful compound for supporting endurance, cardiovascular health, and overall metabolic regulation..