MK‑677 (Ibutamoren) is an orally active, non-peptide growth hormone secretagogue that acts by binding to the ghrelin receptor (GHS-R1a). By mimicking the natural hormone ghrelin, it stimulates the pituitary gland to release growth hormone (GH) and increases circulating levels of insulin-like growth factor 1 (IGF‑1). This modulation influences a wide array of metabolic, enzymatic, and signaling pathways, promoting tissue growth, repair, and regeneration. MK‑677 has been shown to support lean muscle development, enhance bone density, improve sleep quality, and aid recovery, making it a versatile compound in research contexts focused on aging, muscle wasting, metabolism, and endocrine function. Its oral bioavailability, long half-life, and selective mechanism distinguish it from peptide-based secretagogues, offering a convenient and effective method for sustaining GH and IGF‑1 levels over time.